Correlation of P53 Expression with Clinicopathological Parameters, Hormone Receptors and HER 2 Neu Status in Breast Carcinoma

Background: Progesterone receptor (PR), estrogen (ER) expression, human epidermal growth factor 2 (HER neu) amplification/ overexpression, and p53 nuclear protein accumulation are all significant prognostic biomarkers in breast cancer (BC). This work aims to assess the co-presence of overexpression with ER, PR, HER neu expression invasive BC specimens by IHC compare their various clinicopathological features. Objectives: To evaluate HER-2neu carcinoma correlate HER-2 parameters. Methods: Cases Modified Radical Mastectomy received from June 2015 May 2017 were studied. In addition hematoxylin eosin sections, immunohistochemical staining was done for p53. The noted findings correlated other Results: Among 86 cases studied most them belonged age group 41-60 years (54, 62.8%). A positive correlation over ER PR tumours Triple Negative noted. Also showed a tumour grade. Conclusion: P53 indicates an aggressive clinical course can be used as marker poor prognosis.